Ep. 129: The Forgotten Source of Oxalates: Your Body’s OWN Production

In this episode we discuss:

 

• How much oxalate your body produces and how it compares to the amount you consume in your diet
• Whether you need to be concerned about vitamin C, hydroxyproline, and glycine converting to oxalates
• How you can reduce the amount of oxalates your body produces
• Which nutrients decrease oxalate production
• How metabolic dysfunction affects oxalate production

 

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

 

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

 

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/ep-129-the-forgotten-source-of-oxalates-your-bodys-own-production/

 

Timestamps:

0:00 – intro 

1:12 – overview of endogenous vs. exogenous oxalates 

5:46 – how much oxalate comes from endogenous production vs. diet 

9:14 – when endogenous oxalate production matters more than dietary oxalate 

15:03 – rare genetic disorders that cause excessive oxalate production: primary hyperoxaluria 

22:36 – the pathways in the liver that lead to oxalate production 

32:41 – other biochemical pathways involved in endogenous oxalate production 

41:19 – deranged metabolic function as a primary driver of glyoxal production and lipid peroxidation 

45:14 – the extent to which glycine and vitamin C contribute to endogenous oxalate formation 

48:00 – how much does hydroxyproline contribute to oxalate production? 

52:06 – the primary precursor to oxalate that’s often ignored (glyoxal) 

55:08 – how oxidative stress drives oxalate production and how antioxidants help 

1:01:20 – what causes the high oxalate levels seen in type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD)? 

1:11:16 – the protective effects of glycine in states of excess oxalate production 

1:15:54 – elevated stress hormones and gluconeogenesis increase oxalate production 

1:22:43 – nutrient deficiencies that contribute to oxalate issues (vitamin B1, vitamin B6, and zinc)