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Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
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The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response
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How stress prevents our mitochondria from effectively producing energy
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How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease
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How sugar and fat cravings result from stress and why listening to them is beneficial
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How adaptations to stress get passed on through generations
Timestamps:
0:00 – intro
2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids
6:05 – the short-term effects of catecholamines
8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
14:40 – the protective effects of uncoupling as a part of the stress response
20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response
37:33 – the effect of acute stress on energy production in mitochondria
45:18– the effect of chronic stress on energy production in mitochondria
48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states
1:05:24 – the relationship between mental health, mood, and metabolic function
1:10:21 – how adaptations to stress get passed on through mitochondrial DNA
1:18:32 – how to best improve mitochondrial function and our health
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