The Energy Balance Podcast

Ep. 97: How To Properly Test For Thyroid Function (Hypothyroidism Part 3)

In this episode we discuss:

• What causes Hashimoto’s hypothyroidism 
• How to properly interpret your thyroid bloodwork (and what your doctor likely doesn’t know about thyroid testing)
• How your cholesterol values can be used as markers of thyroid status 
• How symptoms like metabolic rate, body temperature, and pulse rate can be more helpful than blood tests when identifying thyroid status 
• Ideal blood test values for optimal thyroid function 

 

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-97-how-to-properly-test-for-thyroid-function-hypothyroidism-part-3

 

Timestamps:

0:00 – intro 

1:17 – what causes Hashimoto’s hypothyroidism and autoimmunity in general

13:30 – how to interpret thyroid blood tests (TSH, T3, T4, rT3) 

31:34 – what reverse T3 means on a blood test and how to interpret rT3 values

34:44 – looking at all thyroid markers together to determine thyroid status 

37:05 – the anti-thyroid effects of reverse T3

40:38 – cholesterol levels as a marker of thyroid status, and the problems with cholesterol levels that are too high or too low

52:34 – the relationship between cholesterol, heart disease, and thyroid status

56:04 – other blood markers that can be indicative of thyroid status (SHBG, ferritin)

57:02 – how we can use symptoms like metabolic rate, body temperature, and pulse rate to determine thyroid status  

1:12:14 – other symptoms that can be used as indicators of thyroid status (low energy, fatigue, low immune function, dry or cracking skin, hair loss brittle nails, slow motility, weight gain, low mood)

Ep. 96: Avoid Low-Carb Diets, Fasting, and Caloric Restriction If You Have Hypothyroidism (Hypothyroidism Part 2)

In this episode we discuss:

• The factors that affect thyroid hormone production, conversion, transport, and uptake

• How high TSH levels cause damage to the thyroid gland

• High-carb diets vs. low-carb diets for thyroid health

• Why restricting calories is not the way to go if you’re struggling with hypothyroidism

• The effects of PUFA and endotoxin on thyroid hormone activity

• The problems with both deficiencies and excesses of iron, iodine, and vitamin A for thyroid health

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-96-avoid-low-carb-diets-fasting-and-caloric-restriction-if-you-have-hypothyroidism-hypothyroidism-part-2/

 

Timestamps:

0:00 – intro 

1:28 – the factors that affect thyroid hormone production, conversion, transport, and uptake

3:45 – the impact of stress on thyroid hormone production and conversion 

5:02 – how the stress hormones and inflammatory cytokines affect thyroid hormone production and conversion

16:44 – thyroid hormones increase sensitivity to stress hormones 

21:44 – elevated free fatty acids, especially PUFA, inhibit thyroid hormone binding

23:26 – how a lack of energy prevents the cells from taking up thyroid hormone

30:00 – how oxidative stress affects thyroid hormone production and the effects of TSH on oxidative stress

38:25 – how a low-carb diet affects thyroid hormone production and conversion, causing a hypothyroid state; high-carb diets vs. low-carb diets for thyroid health

47:46 – insulin resistance is associated with reduced thyroid hormone conversion, but this doesn’t mean you should avoid carbohydrates  

51:39 – how caloric restriction affects thyroid status

55:04 – the effects of fasting on thyroid status

56:42 – T3 has positive feedback on its own production and what this means for thyroid hormone replacement

1:00:01 – the effects of PUFA and endotoxin on thyroid hormone activity

1:04:30 – the effects of micronutrients, specifically iron, vitamin A, selenium, and iodine, on thyroid hormone production, conversion, and activity

1:16:30 – increased thyroid activity increases macronutrient and micronutrient needs, but also improves micronutrient retention in the long-term

1:19:15 – the effects of environmental toxins (pesticides, industrial chemicals, heavy metals, etc.) on thyroid hormone production, conversion, and activity

1:25:20 – the effect of sleep on thyroid hormone production and conversion 

Ep. 95: Hypothyroidism In Context & Thyroid Hormone Basics (Hypothyroidism Part 1)

In this episode we discuss:

• Why hypothyroidism is not the root cause of your issues
  

• Why TSH on its own is not a good marker of thyroid status

• The importance of thyroid hormones for sex hormone production, gut health, and immune function

• T3’s effects on autophagy, mitochondrial biogenesis, and uncoupling

• Whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-95-hypothyroidism-in-context-thyroid-hormone-basics-hypothyroidism-part-1/ 

 

Timestamps:

0:00 – intro 

1:19 – an introduction to hypothyroidism and common symptoms of hypothyroidism

9:02 – the broader biological context of hypothyroidism and hypothyroidism as a low metabolic state 

12:45 – why hypothyroidism is not the root cause

16:23 – the basics of the different thyroid hormones and their regulation

19:54 – the hypothalamic-pituitary-thyroid axis and the nuances within the negative feedback loops

24:45 – the basics of thyroid hormone production

29:37 – the basics of thyroid hormone conversion

35:17 – the larger context of thyroid hormone production and conversion

38:58 – the basics of thyroid hormone transport  

41:44 – the basics of thyroid hormone uptake

46:23 – the nutrients involved in thyroid hormone production and conversion

50:26 – the cellular effects of T3 (metabolic stimulation, uncoupling, autophagy, mitochondrial biogenesis, steroidogenesis from cholesterol)

57:29 – the effects of T3 on gut health, immune function, and aging

1:03:08 – whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign

1:08:41 – the relationship between vitamin A and thyroid hormones 

Ep. 94: How Stress Crashes Your Metabolism & Why Hormesis Is NOT The Answer (Stress & Mitochondria Part 2)

In this episode we discuss:

• Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
  

• The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response

• How stress prevents our mitochondria from effectively producing energy

• How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease

• How sugar and fat cravings result from stress and why listening to them is beneficial

• How adaptations to stress get passed on through generations

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/

 

Timestamps:

0:00 – intro 

2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids

6:05 – the short-term effects of catecholamines

8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling

14:40 – the protective effects of uncoupling as a part of the stress response

20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response

37:33 – the effect of acute stress on energy production in mitochondria

45:18– the effect of chronic stress on energy production in mitochondria

48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states

1:05:24 – the relationship between mental health, mood, and metabolic function

1:10:21 – how adaptations to stress get passed on through mitochondrial DNA

1:18:32 – how to best improve mitochondrial function and our health

Ep. 93: How Cortisol Affects Your Mitochondria & Acute vs. Chronic Stress (Stress & Mitochondria Part 1)

In this episode we discuss:

• Why stress is not your friend
  

• The effects of cortisol on your mitochondria

• Hans Selye’s general adaptation syndrome

• How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism

• Why acute stress does not lead to improved health via hormesis

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-93-how-cortisol-affects-your-mitochondria-acute-vs-chronic-stress-stress-mitochondria-part-1-ep-93/ 

 

Timestamps:

3:00 – an introduction to the paper: mitochondria as key components of the stress response   

4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance  

23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response 

31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts 

34:04 – how long-term stress causes degeneration 

34:55 – functions of the mitochondria 

38:54 – mitochondria upregulate energy production in response to stress 

41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol)

44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time

50:30 – how mitochondria respond to excess stress and how this relates to fat gain

59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism

Ep. 92: Celebrating Ray Peat

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-92-celebrating-ray-peat/

Ray Peat's Website: http://raypeat.com/

Ray Peat Interviews, Articles, Related Websites, and Other Resources: https://www.selftestable.com/ray-peat-stuff/sites

 

 

 

Ep. 91: Cod Liver Oil Dangers, The Croissant Diet, and Insulin-Resistant Fat Cells (Q & A)

In this episode we discuss:

• Whether cod liver oil is an ideal source of vitamin A/retinol

• Whether we should be concerned about the omega-3 content of cod liver oil (CLO)

• The idea that we want our fat cells to be insulin resistant to lose fat

• Whether keeping insulin low is the key to fat loss

• What hormones regulate fat loss

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-91-cod-liver-oil-dangers-the-croissant-diet-and-insulin-resistant-fat-cells-q-a/ 

 

Timestamps:

2:54 – what we think about cod liver oil as a vitamin A source  

9:50 – why someone may benefit from cod liver oil, and why it likely isn’t a result of the retinol  

10:56 – the immunosuppressive effects of omega-3s 

14:25 – the major problems with omega-3s, including cod liver oil specifically 

25:33 – clarifying our thoughts on the Croissant Diet 

28:26 – burning saturated fat versus burning PUFA and whether PUFA create more ROS than saturated fats  

31:41 – what we think of the idea that consuming saturated fats will allow for fat loss by causing insulin resistance in the adipocytes (fat cells)  

42:50 – why increasing fat burning doesn’t inherently lead to increased fat loss 

47:11 – whether increasing satiety is the key to fat loss 

 

Ep. 90: Eating 5,000 Calories Per Day, Fish Oil, Water Weight vs. Body Fat, Paleo-Ketogenic Diet (Q & A)

In this episode we discuss:

• Whether fish oil is beneficial due to its anti-inflammatory and cholesterol-lowering effects

• Our thoughts on the benefits from a paleo-ketogenic diet

• What to do if you’re dealing with dental issues from sugar consumption

• Our experiences eating 5,000 to 6,000 calories per day

• The best time to eat the carrot salad

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-90-eating-5000-calories-per-day-fish-oil-water-weight-vs-body-fat-paleo-ketogenic-diet-q-a/ 

 

Timestamps:

2:44 – why fish oil shows anti-inflammatory and cholesterol-lowering effects, and why this doesn’t mean they’re beneficial 

11:25 – eating carrots with a meal versus away from a meal 

17:27 – our thoughts on the benefits from a paleo-ketogenic diet 

28:45 – which coral calcium supplement we recommend 

32:33 – dental issues from sugar consumption 

39:45 – what we think of orange juice with added calcium 

41:36 – how to determine whether weight gain is due to water weight or body fat  

51:57 – our experiences eating 5,000-6,000 calories per day 

1:03:23 – whether it’s helpful to use calorie calculators and context to consider when it comes to calorie calculators 

1:11:20 – how our current diets vary in contrast to when we were eating 5,000-6,000 calories per day

 

Ep. 89: The Anti-Inflammatory Effects of Fruit Juice and The Hormonal Effects of PUFA vs. SFA

In this episode we discuss:

• Whether PUFA causes more oxidative stress than saturated fats

• How PUFA intake affects testosterone

• Whether fruit juice should be avoided for blood sugar regulation

• The effects of fruit juice on inflammatory markers and endotoxin

• Whether fruit juice has the same effects as soda

 

Check out the Energy Balance Solution group coaching program: https://jayfeldmanwellness.com/solution

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-89-the-anti-inflammatory-effects-of-fruit-juice-and-the-hormonal-effects-of-pufa-vs-sfa/ 

 

Timestamps:

4:10 – the effects of different dietary fat compositions on phospholipid and neutral lipid compositions in the testicles  

18:31 – the effects of different dietary fat composition on oxidative damage and antioxidant status in the testicles

29:44 – the effects of different dietary fat composition on hormone production and metabolism in the testicles 

38:26 – introducing the next study discussing the effects of orange juice on a high-fat, high-carbohydrate meal in terms of inflammation and endotoxin  

44:14 – the effects of orange juice on blood glucose and insulin sensitivity 

47:55 – the effects of orange juice on ROS production, TLR2 and TLR4 expression, and plasma endotoxin 

51:35 – factors that could account for the benefits of orange juice 

 

Ep. 88: Whether Soy Is Estrogenic And Causes Infertility

In this episode we discuss:

• The hormonal effects of compounds in soy

• How the effects of BPA compare to soy 

• Whether soy is estrogenic and causes infertility

• Whether the amount of soy typically consumed is sufficient to create these effects

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-88-whether-soy-is-estrogenic-and-causes-infertility/ 

 

Timestamps:

3:06 – overview of the study we’ll be discussing 

5:57 – compounds in soy have potentially estrogenic thymic, immune, and hormonal effects 

10:20 – compounds in soy oppose testosterone and reduce its production 

13:33 – whether animal research translates to humans 

16:40 – BPA has anti-fertility effects in males that are parallel to supplemental estrogen 

27:39 – corn oil causes weight gain despite the same number of calories consumed

32:11 – the reproductive effects of soy, BPA, and estradiol 

44:50 – the amount of soy required to cause these reproductive effects