The Energy Balance Podcast

Ep. 77: Why You DON’T Want to Force Autophagy, Mitochondrial Biogenesis, & Uncoupling (Hormesis Part 3)

In this episode we discuss:

• Why the stress caused by calorie restriction, exercise, cold thermogenesis, fasting, ketogenic diets, Wim Hoff breathing, and supplements like resveratrol is not supportive of our health

• Why autophagy, mitochondrial biogenesis, and uncoupling are not always beneficial

• Whether being tolerant to stress is a sign of health

• Why it’s virtually impossible to apply hormesis in a practical sense

• The difference between reactive oxygen species production in a high energy state versus a low energy state

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-77-why-you-dont-want-to-force-autophagy-mitochondrial-biogenesis-uncoupling-hormesis-part-3/ 

 

Timestamps:

3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis

13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations

28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis  

37:05 –the difference between producing ROS in a high energy state versus a low energy state

49:16 – the low energy, high ROS state is a feature of degenerative conditions

 

Ep. 76: Why Caloric Restriction Is NOT Responsible For Lifespan Extension (Hormesis Part 2)

In this episode we discuss:

• How the largest body of evidence cited in favor of hormesis actually doesn’t support it at all

• Why caloric restriction is NOT responsible for slowing aging and extending lifespan (and what is actually responsible)

• The many factors that confound the calorie restriction research (including differences between organisms, poor research design, amino acid restriction, PUFA, endotoxin, and more)

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/ 

 

Timestamps:

3:36 – the physiology of hormesis and the general support for hormesis

12:54 – outlining the problems with hormesis

18:51 – how differences between organisms confound the caloric restriction research 

37:34 – the problem with using proxy markers to evaluate health effects and the importance of context

48:20 – how differences between organisms confound the caloric restriction research (cont.)

51:58 – how hydration status and macronutrient ratios confound the caloric restriction research

55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables

1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research

1:11:58 – how PUFA confounds the caloric restriction research

1:30:09  – how endotoxin and gut health confound the caloric restriction research

 

Ep. 75: Hormesis As An Anti-Scientific Defense For Industrial Pollution And Chemical Exposure (Hormesis Part 1)

In this episode we discuss:

• How the concept of hormesis defends our exposure to toxic chemicals, industrial contaminants and pollutants, and ionizing radiation

• Why hormesis is a dangerous, anti-scientific idea masquerading as science

• The suspicious history of hormesis and its current definitional problems 

• The important distinction between stress and adaption

• The problems with the terms “eustress” and “distress” 

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-75-hormesis-as-an-anti-scientific-defense-for-industrial-pollution-and-chemical-exposure-hormesis-part-1/ 

 

Timestamps:

3:36 – an introduction to hormesis as a means to reverse aging and reverse chronic health conditions 

6:45 – what is hormesis

12:34 – the suspicious history of hormesis  

16:20 – the definitional problems with hormesis

34:51 – how hormesis is influencing dangerous public health policies

47:35 – the difference between stressor effects and specific effects, creating a distinction between stress and adaptation, and the problems with the terms “eustress” and “distress”

 

Ep.74: Refuting Nutrition With Judy’s “Thoughts on the Ray Peat Diet” (Part 2)

In this episode we discuss:

• Why low-carb diets are inherently stressful

• How carbohydrates oppose stress and decrease the stress hormones

• Why carbohydrates ARE essential and why their intake plays a vital role in our endocrine systems  

• Whether most people have hypothyroidism and how carnivore diets can cause hypothyroidism

• Why carnivore diets are NOT ideal for gut health even if they improve symptoms in the short-term 

• The real reason why people are moving from a carnivore diet to a “Ray Peat Diet”

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-74-refuting-nutrition-with-judys-thoughts-on-the-ray-peat-diet-part-2/ 

 

Timestamps:

3:03 – why low-carb diets drive physiological stress and carbohydrates oppose stress

21:51 – why carbohydrates are essential and why our endocrine systems are so tightly tuned to carbohydrate intake

29:19 – do most people have hypothyroidism?

44:38 – is hypothyroidism ever the root problem?

53:28 – how carnivore diets can cause hypothyroidism

1:01:36 – whether taking exogenous steroid hormones (like pregnenolone or progesterone) will increase cortisol

1:12:19 – should we focus on gut health over thyroid health?

1:23:31 – why are people really moving from carnivore to a “Ray Peat Diet?”

Ep. 73: Refuting Nutrition With Judy’s “Thoughts on the Ray Peat Diet” (Part 1)

In this episode we discuss:

• Why our brains favor glucose as their fuel source

• Why fat is less energetically favorable as a fuel compared to carbohydrates  

• The problem with reducing the bioenergetic view to the “Ray Peat diet”  

• The amount of carbohydrates our bodies can handle before storing them as fat

• Whether consuming carbohydrates causes Alzheimer’s disease 

• Whether the raising of our blood sugar and the production of insulin is wasteful and harmful

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-73-refuting-nutrition-with-judys-thoughts-on-the-ray-peat-diet-part-1/ 

 

Timestamps:

3:01 – an introduction to Nutrition With Judy’s article on Ray Peat

7:41 – energy and metabolism are at the core of the bioenergetic view

18:43 – the problem with reducing the bioenergetic paradigm to the “Ray Peat diet” and the importance of context

29:28 – why carbohydrate oxidation is more energetically favorable to fat oxidation

41:09 – why consuming carbohydrates does not make you fat or prevent you from oxidizing fat

45:35 – our body’s impressive capacity for carbohydrate oxidation and storage

58:06 – glucose requirements in the brain other than energy production

1:00:21 – why the increased production of CO2 from carbohydrate oxidation further supports the energy favorability of carbohydrates

1:00:58 – does consuming carbohydrates cause Alzheimer’s disease?

1:06:05 – why the raising of blood sugar and the production of insulin is not wasteful or harmful

 

Ep. 72: Dental Health on a High-Sugar Diet & How To Determine What’s Blocking Energy Production (Q & A)

In this episode we discuss:

• Which vitamins and minerals are most relevant to dental health

• How our gut health and microbiome can affect oral health 

• How to prevent potential dental harm on a high-sugar diet/from consuming fruits and other sugar-containing foods  

• How to determine the order of operations for making lifestyle adjustments 

• The first step to addressing virtually all health issues
  

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-72-dental-health-on-a-high-sugar-diet-how-to-determine-whats-blocking-energy-production-q-a/ 

 

Timestamps:

2:49 – factors to consider for supporting dental health and preventing tooth erosion and decay

23:10 – how to determine the order with which to address different aspects of health to address first and how to determine what’s blocking our energy production

 

Ep. 71: Weight Gain From Replenishing Glycogen & Calcium Sources Other Than Dairy (Q & A)

In this episode we discuss:

• How much weight gain can be attributed to increases in glycogen storage when adding in carbohydrates

• At what point weight gain would be a sign of an underlying metabolic issue

• The best ways to get calcium if you’re not eating dairy  

• Potential ways to improve your tolerance to dairy

• The best form of calcium to use as a calcium supplement 

• Which calcium-containing vegetables might be worth including in your diet 
  

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-71-weight-gain-from-replenishing-glycogen-calcium-sources-other-than-dairy-q-a/ 

 

Timestamps:

3:13 – how much weight gain can be attributed to refilling glycogen

25:02 – calcium sources other than dairy

 

Ep. 70: Pro-Metabolic Supplements For Fatty Liver Disease (NAFLD Part 8)

In this episode we discuss:

• The optimal amount of exercise for fatty liver disease 

• How stress impacts fatty liver disease and basic ways to reduce stress 

• Supplements that help the liver clear fat to reverse fatty liver 

• The best supplements for raising metabolism to reverse fatty liver disease 

• Supplements that reduce inflammation and oxidative stress in fatty liver disease 
  

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-70-pro-metabolic-supplements-for-fatty-liver-disease-nafld-part-8/

 

Timestamps:

2:57 – the importance of exercise/movement and not being sedentary for fatty liver disease

8:58 – the impact of stress on fatty liver disease and basic ways to reduce stress

16:31 – the best choline supplement for fatty liver disease and when it makes sense to supplement choline or methionine

26:40 – B vitamins for fatty liver disease

32:40 – taurine and TUDCA for fatty liver disease

41:36 – glycine for fatty liver disease

48:52 – essential amino acids for fatty liver disease

50:42 – theanine and tea for fatty liver disease

52:36 – vitamin E and vitamin C for fatty liver disease

57:35 – aspirin for fatty liver disease

1:00:00 – lactoferrin for fatty liver disease

1:03:10 – antimicrobials for fatty liver disease

1:05:23 – caffeine and coffee for fatty liver disease

1:09:43 – inosine for fatty liver disease

1:11:00 – the impact of thyroid hormones on fatty liver disease

1:20:24 – testosterone and other steroid hormones for fatty liver disease

 

Ep. 69: Carb Deficiencies, Saturated Fat Intake, & The Best Diet For Fatty Liver (NAFLD Part 7)

In this episode we discuss:

• How carbohydrate deficiencies can drive fatty liver disease

• The particular type of fat you’ll want to avoid if you have fatty liver disease

• The optimal amount of protein, fat, and carbs for reversing fatty liver disease

• The order of dietary adjustments for fatty liver disease and why this matters

• Whether reducing fructose intake is necessary for treating or reversing fatty liver disease 

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-69-carb-deficiencies-saturated-fat-intake-the-best-diet-for-fatty-liver-nafld-part-7/ 

 

Timestamps:

3:38 – the importance of dietary protein and choline for fatty liver

14:41 – the best types of fats and how much of these fats to eat for fatty liver

28:30 – the ideal carbohydrate sources for reversing fatty liver and major considerations to keep in mind

40:43 – the importance of experimentation when implementing dietary changes

47:05 – why carbohydrates are so effective at opposing stress, increasing metabolism, and reducing oxidative stress

49:22 – the importance of nutrient density and particular micronutrients for fatty liver disease

52:56 – why it’s important to minimize alcohol intake in fatty liver disease and how to protect against the effects of alcohol on the liver

56:12 – how diet, lifestyle, and supplements fit together to create a holistic approach to treating or reversing fatty liver

 

Ep. 68: Oxidative Stress, Choline Deficiency, and Exporting Liver Fat (NAFLD Part 6)

In this episode we discuss:

• How excess oxidative stress causes fat to accumulate in the liver

• How a choline or methionine deficiency can contribute to fatty liver

• Another mechanism by which PUFA cause fatty liver disease

• How folate and vitamin B12 deficiencies can contribute to fatty liver

• How PUFA decrease LDL and why this is NOT beneficial for general metabolic health or liver health

 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

 

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-68-oxidative-stress-choline-deficiency-and-exporting-liver-fat-nafld-part-6/

 

Timestamps:

3:48 – how fat gets exported from our livers and why it matters in NAFLD

8:40 – how a choline, methionine, folate, or B12 deficiency can inhibit the liver’s ability to export fat

19:05 – how oxidative stress caused by PUFA and other factors inhibits the liver’s ability to export fat

27:50 – research showing that PUFA causes oxidative stress that inhibits the liver’s ability to export fat

42:11 – why lowering LDL by eating PUFA is NOT beneficial, both for general metabolic health and liver health

59:57 – other factors that drive oxidative stress and inhibit the liver’s ability to export fat